Transhumanism & Gout?

no, it’s not a Googlewhack. Hang on, I’ll just test that assertion. Nope, it’s definitely not a googlewhack

I read this article in the New Scientist earlier today and got rather excited. I’ll explain why in a minute. I wanted to share it with you but I knew – as you’ll have just confirmed if you clicked on the link – that the article is behind a pay wall. New Scientist is the one publication I subscribe to so can read stuff like that, but we’re a tiny minority.

So I went looking for another source for the story and came across this rather dry abstract. And because I’m that sort of nerd, I read it. And got almost as excited again.

That research may have filled a gap in our knowledge regarding the effects of ph on the human body. As a gout sufferer for the last 10 years I have had to research the condition and possible treatments or regimes. I have, by trial and error, discovered what works for me: an alkaline diet. The question is why?

The research is absolutely nothing whatsoever to do with gout. But it may, nevertheless, answer that question. What it is revealing is that if your cells are in an alkaline environment rather than acid, the potassium ion gates are opened and positive ions (which actually constitute or create the alkaline environment in the first place) are able to rush in.

As I’d just learned from the first story – the one I wanted to share – opening the gateway to positive ions turns out to be a good thing if you’re a mammalian cell. It allows the scavenging of “free radicals” like oxygen ions which are poison to the inside of a cell, but are formed as the waste product of cellular “digestion” and one or two other intra-cellular mechanisms.

This would explain why alkalinity tends to promote healing and dampen the infamous “inflammatory response” (which is a principle mechanism for most disease), so I immediately conjecture that the same process, through some related mechanism, also reduces the likelihood of precipitation of uric acid crystals from the blood into the joints – which is the precise cause of gout.

This matters because what I think we are gradually confirming is the reason that alkalinity is good for health generally, not just gout. Many sites around the web have been pumping out the Alkalinity message for over a decade. Many, unfortunately, are misguided nonsense talking about “Blood Alkalinity” and the importance of preventing “acid blood”. In fact, if your serum ph ever went acid, you’d be dead, pdq. Amongst other things, your haemoglobin wouldn’t be able to bind to enough oxygen to let you breath properly.

Blood ph is remarkably stable (typically 7.35-7.45) because it is homeostatically controlled. i.e. it will take whatever it needs from the body to ensure that it NEVER becomes acidic or too alkaline. If you are heading towards acidic, what will happen in the short term is that you’ll start breathing faster as your body insists on ejecting carbon dioxide, the result of which is a change in the serum bicarbonate production and rise in ph back to normal, if you’re lucky. If the problem is more long term your bones will start dissolving as the homeostasis leaches calcium to maintain the higher alkaline ph. Or the liver will break down more than usual nucleic acids resulting from protein digestion into urea, or worse, uric acid – which has the painful tendency to drop out of precipitation from the blood into the most painful places it possibly could – the joints of big toes for instance.

The abstract is essentially explaining the mechanism by which an alkaline diet will flood the system with positive ions, suppressing the requirement to leach the calcium or produce uric acid and leaving the body’s building blocks right where they belong. And allowing the cleanup of free radicals. So now we know…

It was impossible to find another source for the original story, unfortunately, but I did find the same source handily pasted into one of Kurzweil’s Transhumanist forums. Which means you can now read it without charge and I’m not the one in breach of copyright (for a change).

It’s obviously on the forum for precisely the reason I wanted to share it with you. One of the biggest challenges in developing “mind-uploading” techniques involves how we map the entire brain non-destructively. That “Positive Switch” story describes what will almost certainly be a major component of the solution to that problem. The same intracellular switches which will one day return Francisco Sepulveda to full normal (possibly better than normal) hearing, will eventually morph into the devices we need to read every cell in the brain for the purpose of mapping it to our digital clone.

And it looks like it could be ready to roll in the next 10-20 years. That’s got to be worth another spliff!